Anti-inflammatory effect of alcoholic extract of Datura stramonium seeds in male rats

Abstract

Background: Regarding the incomplete treatment and occurrence of side effects by chemotherapeutic agents in patients suffering from inflammation, new effective strategies are strongly needed. Objective: To investigate the anti-inflammatory effect of alcoholic extract of Datura stramonium seeds on inflammation. Methods: This was an experimental study carried out in medical school of Shahed university. Induction of acute inflammation was achieved by injecting formalin, xylene and acetic acid into hind paw, ear, and peritoneum of male mice, respectively. The light absorption values of solution (Evince blue dye in circulation) collected from segments with inflammation, considered as data. In chronic inflammation, the data was obtained by weighing of cotton plate implanted into groin region after 7 days. In treatment group the extract (50 mg/kg) was injected (i.p) 20 minutes before the experiments. Findings: The size of inflammation produced by formalin and acetic acid was significantly reduced (52.28±2.2% and 28.8±3.6%), respectively. Comparing the data associated with the weight of implanted cotton plates, the extract showed to have little effect on decreasing the size of chronic inflammation, yet statistically significant (p