Prevalence of Alpha and Beta-Thalassemia Mutations Among Carriers of Thalassemia in Shadegan City, Southwest of Iran
| Author | Amin Doosti Irani | en |
| Author | Zahra Cheraghi | en |
| Author | Saied Bitaraf | en |
| Author | Parvin Cheraghi | en |
| Author | Saeid Safiri | en |
| Orcid | Zahra Cheraghi [0000-0001-9041-559X] | en |
| Issued Date | 2015-08-28 | en |
| Abstract | Background:: We aimed to investigate the alpha and beta-thalassemia mutations and assess the association of hematologic indices with mutations. Patients and Methods:: In this cross sectional study, we assessed 275 suspected thalassemia carriers. Amplification refractory mutation system-polymerase chain reaction and Gap PCR were used for detection of mutations. Results:: CD 36 - 37 (-T) and -α3.7/αα were most common mutations. Mean of corpuscular hemoglobin and corpuscular volume was less among beta-thalassemia carriers in comparison to alpha-thalassemia carriers (P = 0.001). Conclusions:: Detected mutations were different from other regions in Iran. After iron therapy, mean of corpuscular volume (MCV) was < 69 fL and mean of corpuscular hemoglobin was < 23 pg, may be classified as beta-thalassemia carriers. | en |
| DOI | https://doi.org/10.17795/zjrms1032 | en |
| Keyword | Alpha-Thalassemia | en |
| Keyword | Beta-Thalassemia | en |
| Keyword | Mutation | en |
| Keyword | Prevalence | en |
| Keyword | Iran | en |
| Publisher | Brieflands | en |
| Title | Prevalence of Alpha and Beta-Thalassemia Mutations Among Carriers of Thalassemia in Shadegan City, Southwest of Iran | en |
| Type | Brief Report | en |
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