The Association of the <i>TNF-α</i>-308G/A Gene with Recurrent Miscarriage Abortions in East Azarbaijan

Abstract

Background: Recurrent pregnancy loss (RPL) is defined as two or more pregnancy losses before 20 weeks gestation. -TNF-α is a pro-inflammatory cytokine that has been proposed a candidate gene for the pathogenesis of RPL. This study aimed to investigate the association of TNF-α-308G/A polymorphism with RPL among East Azarbaijan population. Methods: The patient group comprised 100 women with the experience of three pregnancy losses and the control group comprised 100 women without any previous history of pregnancy loss. Genotype TNF-α-308G/A was detected using PCR-RFLP assay. Results: The observed frequencies of GG and GA genotypes of TNF-α-308G/A polymorphism were respectively 84% and 16% in the patient group and 81% and 19% in the control group. AA genotype was not observed in any of the groups. Conclusions: Our results suggest that the TNF-α-308G/A polymorphism is not associated with RPL in East Azarbaijan women.