The Association of the <i>TNF-α</i>-308G/A Gene with Recurrent Miscarriage Abortions in East Azarbaijan
| Author | Ayda Bahmani | en |
| Author | Mortaza Jabbarpour Bonyadi | en |
| Author | Simin Tagavi | en |
| Orcid | Mortaza Jabbarpour Bonyadi [0000-0003-3216-2947] | en |
| Issued Date | 2018-09-30 | en |
| Abstract | Background: Recurrent pregnancy loss (RPL) is defined as two or more pregnancy losses before 20 weeks gestation. -TNF-α is a pro-inflammatory cytokine that has been proposed a candidate gene for the pathogenesis of RPL. This study aimed to investigate the association of TNF-α-308G/A polymorphism with RPL among East Azarbaijan population. Methods: The patient group comprised 100 women with the experience of three pregnancy losses and the control group comprised 100 women without any previous history of pregnancy loss. Genotype TNF-α-308G/A was detected using PCR-RFLP assay. Results: The observed frequencies of GG and GA genotypes of TNF-α-308G/A polymorphism were respectively 84% and 16% in the patient group and 81% and 19% in the control group. AA genotype was not observed in any of the groups. Conclusions: Our results suggest that the TNF-α-308G/A polymorphism is not associated with RPL in East Azarbaijan women. | en |
| DOI | https://doi.org/10.5812/jkums.84383 | en |
| Keyword | <i>TNF-α</i>-308G/A polymorphism | en |
| Keyword | East Azarbaijan | en |
| Publisher | Brieflands | en |
| Title | The Association of the <i>TNF-α</i>-308G/A Gene with Recurrent Miscarriage Abortions in East Azarbaijan | en |
| Type | Research Article | en |
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