Fast Effect of Buprenorphine on Opioid-dependent Patients with Suicidal Ideation: A Novel Approach
| Author | Jamshid Ahmadi | en |
| Author | Mina Sefidfard Jahromi | en |
| Issued Date | 2018-06-30 | en |
| Abstract | Background: Buprenorphine is usually administered to manage opioid use disorder and pain syndromes. It could be a proper treatment option for suicidality, resistant depression, self-destructive behavior, and anxiety. Buprenorphine has a considerable abuse potential that confines its administration in patients committing suicide with a background of substance abuse. Objectives: The current study aimed to clarify the influence of different doses of buprenorphine on opioid-dependent patients committing suicide over a 2-day period in a randomized, clinical trial (RCT). Patients and Methods: Patients were randomly assigned into 3 groups. Twenty-three suicidal male patients who met the DSM-5 (diagnostic and statistical manual of mental disorders) criteria for opioid dependence and sought treatment were recruited. Patients randomly received 32, 64, or 96 mg of buprenorphine as a single high-dose only and were hospitalized in a psychiatric inpatient ward. Out of the 23 patients, 9 (39.2%), 8 (34.8%), and 6 (26%) received 32, 64, and 96 mg of buprenorphine, respectively. Psychometric assessment was performed using the Beck scale for suicidal ideation (BSSI) and interview. All patients completed the 2-day treatment period. The results indicated a significant decrease in BSSI scores in each of the 3 groups (P < 0.05), but there was no difference in the outcome between the groups (P = 0.30). Conclusions: The current study results indicated that a single high-dose of buprenorphine could provide a speedy and safe means to treat suicidality in opioid-dependent patients. | en |
| DOI | https://doi.org/10.5812/ijhrba.57510 | en |
| Keyword | Buprenorphine | en |
| Keyword | Depressive Disorder-Major | en |
| Keyword | Suicide | en |
| Keyword | Opioid | en |
| Publisher | Brieflands | en |
| Title | Fast Effect of Buprenorphine on Opioid-dependent Patients with Suicidal Ideation: A Novel Approach | en |
| Type | Research Article | en |
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