Similar efficacy of vancomycin and teicoplanin in treatment of catheter related infection in hemodialysis patients

Abstract

Introduction: Catheter related infection is one of the most important complications of vascular access devices. Treatment of these complications is important and life saving. The most common causative organisms are gram-positive bacteria especially staphylococcus. Vancomycin and teicoplanin are two antibiotics which widely used for invasive beta-lactam-resistant Gram-positive infections. In this study, we aimed to compare efficacy of vancomycin and teicoplanin in treatment of catheter related infection. Material and Methods: In this clinical trial, 43 patients with catheter infection were enrolled. Diagnosis was based on clinical criteria. 22 patients were received teicoplanin 800mg intra-venous loading dose and 400mg at days 2th, 3th,5th,12th,19th and 21 patients received vancomycin 1gr intra venous loading dose and 500mg every 5 days and for 3 weeks. A criterion for treatment response was absence of fever after 72 hours. Results: %57.1 patients who received vancomycin and %68.2 patients who received teicoplanin had clinical response (p=0.454). In patients who received vancomycin, one case developed red man syndrome and one case developed diarrhea (9.5%) and in tiecoplanin group one patient developed rash (9.1%). Conclusion: Our findings show that there is no significant difference between two groups in treatment of catheter related infection in hemodialysis patients