The Role of Next Generation Sequencing in Diagnosis of Brain Tumors: A Review Study

AuthorSadegh Shirianen
AuthorYahya Daneshboden
AuthorSaranaz Jangjooen
AuthorAmir Ghaemien
AuthorArash Goodarzien
AuthorMaryam Ghavideldarestanien
AuthorAhmad Emadien
AuthorArman Aien
AuthorAkbar Ahmadien
AuthorJafar Aien
OrcidSadegh Shirian [0000-0003-4137-9056]en
Issued Date2020-01-31en
AbstractSince the number of prognostic and predictive neuro-oncologic genetic markers is steadily increasing, a comprehensive analysis of the molecular techniques used to examine neuro-oncology samples is vastly required. Molecular analysis and profiling of brain malignancies result in improved diagnostic accuracy, target identification, and predictive prognosis. Application of high-throughput molecular approaches, such as next generation sequencing (NGS), to analyze brain tumors has provided a large amount of molecular information. In the clinical practice, the application of NGS has been increased, which has consequently improved the treatment option for brain cancer as well as other types of malignancies. Target therapy has recently become one of the most promising treatment options for various tumors, especially brain tumors. In this review, we provided and summarized high-throughput genomic studies, such as NGS technique, that could independently identify the integrated management and diagnosis of primary human brain tumors across a variety of entities with pathognomonic genetic alterations.en
DOIhttps://doi.org/10.5812/ans.68874en
KeywordNext-Generation Sequencingen
KeywordBrain Tumorsen
KeywordTarget Identificationen
KeywordGenetic Markersen
PublisherBrieflandsen
TitleThe Role of Next Generation Sequencing in Diagnosis of Brain Tumors: A Review Studyen
TypeReview Articleen

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