Comparison of the Effects of Oral Sucrose 30% and 50% on the Pain of Injection of Hepatitis B Vaccine in Newborns
| Author | Ali Imani | en |
| Author | Fatemeh Moradi | en |
| Orcid | Ali Imani [0000-0003-1225-5898] | en |
| Orcid | Fatemeh Moradi [0000-0002-2401-3151] | en |
| Issued Date | 2020-01-31 | en |
| Abstract | Background: Uncontrolled pain in newborns results in permanent damage to the growth components of cognitive development and changes in response to subsequent painful stimuli. Objectives: The aim of this study was to comparison of the effects of oral sucrose 30% and 50% on the pain of injection of hepatitis B vaccine in newborns. Methods: In these triple-blind clinical trial conducted at Amir-al Momenin Hospital in Semnan, 91 term infants were selected and randomly divided into three groups. Two minutes prior to intramuscular injection of hepatitis B vaccine in the case group, 2 mL of sucrose solution 30% or 50% and in the control group the same volume of sterile water was given orally to the infant. Prior to the administration of sucrose, immediately after injection and 5 minutes after injection the Neonatal Infant Pain Scale (NIPS) was used to assess pain. For statistical data analysis, Mann-Whitney, chi-square, Kruskal-Wallis, One-Way ANOVA and Dunnett tests at a significance level of 5% were used. Results: The results showed that sucrose 30% and 50% significantly reduced pain during, immediately, and 5 minutes after injection (P < 0.05). Conclusions: In general, high concentrations of sucrose can relieve the pain of vaccination and can be used in the clinic. | en |
| DOI | https://doi.org/10.5812/zjrms.91557 | en |
| Keyword | Infant Pain | en |
| Keyword | Sucrose | en |
| Keyword | Intramuscular Injection | en |
| Keyword | Hepatitis B Vaccine | en |
| Publisher | Brieflands | en |
| Title | Comparison of the Effects of Oral Sucrose 30% and 50% on the Pain of Injection of Hepatitis B Vaccine in Newborns | en |
| Type | Research Article | en |
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