Haplotype Effect of Two Human Leukocyte Antigen-G Polymorphisms of rs1736933 and rs2735022 on the Recurrent Pregnancy Loss
| Author | Zahra Najafi | en |
| Author | mohammad khalaj-kondori | en |
| Author | Mohammad Ali Hosseinpour Feizi | en |
| Author | Shamsi Abbasaliizadeh | en |
| Orcid | mohammad khalaj-kondori [0000-0001-9231-889X] | en |
| Issued Date | 2020-12-31 | en |
| Abstract | Background: Recurrent Pregnancy Loss (RPL) is a multifactorial disease that affects 1-3% of couples. Since Human Leukocyte Antigen-G (HLA-G) gene is involved in fetal maternal immune tolerance, mutations in the HLA-G gene can affect the success rate of pregnancy. Objective: The present study aims to investigate the haplotype effect of rs1736933 and rs2735022 polymorphisms found in the HLA-G gene on the RPL. Methods In this case-control study, participants were 100 women with RPL and 80 women with normal fertility in northwestern Iran. The HLA-G gene promoter was amplified by Polymerase Chain Reaction (PCR) method and sequenced. The genotype and allele frequencies of the two polymorphisms were compared between the two groups by using t-test in SPSS software version 22. Haplotype analysis was performed using PHASE 2.1 and Haploview 4.2 applications Findings: C allele and CC genotype in rs2735022 polymorphism and the G allele and GG genotype in rs1736933 polymorphism showed a significant association with the RPL (P | en |
| DOI | https://doi.org/ | en |
| Keyword | Recurrent pregnancy loss | en |
| Keyword | Polymorphism | en |
| Keyword | Haplotype | en |
| Keyword | Human Leukocyte antigen-G | en |
| Publisher | Brieflands | en |
| Title | Haplotype Effect of Two Human Leukocyte Antigen-G Polymorphisms of rs1736933 and rs2735022 on the Recurrent Pregnancy Loss | en |
| Type | Research Article | en |