Diabetes Mellitus: Findings from 20 Years of the Tehran Lipid and Glucose Study
| Author | Azra Ramezankhani | en |
| Author | Hadi Harati | en |
| Author | Mohammadreza Bozorgmanesh | en |
| Author | Maryam Tohidi | en |
| Author | Davood Khalili | en |
| Author | Fereidoun Azizi | en |
| Author | Farzad Hadaegh | en |
| Orcid | Fereidoun Azizi [0000-0002-6470-2517] | en |
| Orcid | Farzad Hadaegh [0000-0002-8935-2744] | en |
| Issued Date | 2018-10-31 | en |
| Abstract | Context: We summarized findings from Tehran lipid and glucose study (TLGS) about different aspects of type 2 diabetes (T2D) over the span of nearly 2 decades. Evidence Acquisition: A review was undertaken to retrieve papers related to all aspects of T2D from the earliest date available up to January 30, 2018. Results: An annual crude incidence rate of 10 per 1000 person-years of follow-up was found for T2D in adult participants. Overall incidence rate of pre-diabetes/T2D was 36.3 per 1000 person-years or about 1% each year among youth. Diabetes was associated with increased risk of CVD [hazard ratio (HR): 1.86, 95% confidence interval (95% CI): 1.57 - 2.27] and mortality [HR: 2.56; 95% CI: 2.08 - 3.16] in the total population. Compared with non-diabetic men and women, their diabetic counterparts survived 1.4 and 0.7 years shorter, respectively, during 15 years of follow-up. Wrist circumference, hyperinsulinaemia, 25-hydroxy vitamin D and increase in alanin aminotranferase provided incremental prognostic information beyond the traditional risk factors for incident T2D in adults. Using decision tree algorithms, a number of high risk groups were found for incident T2D. A probability of 84% was found for incidence of T2D among a group of men with fasting plasma glucose (FPG) > 5.3 mmol/L and waist to height ratio (WHtR) > 0.56, and women with FPG > 5.2 mmol/L and WHtR > 0.56. Conclusions: Original TLGS studies have contributed greatly to clarify important evidence regarding the epidemiology and risk factors for T2D among Iranian population. | en |
| DOI | https://doi.org/10.5812/ijem.84784 | en |
| Keyword | Diabetes | en |
| Keyword | Tehran Lipid and Glucose Study | en |
| Keyword | Cardiovascular Disease | en |
| Publisher | Brieflands | en |
| Title | Diabetes Mellitus: Findings from 20 Years of the Tehran Lipid and Glucose Study | en |
| Type | Review Article | en |
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