Effect of Serum Ferritin Level on the Response to Standard Chemotherapy in Acute Myeloid Leukemia Patients
| Author | Nasrin Namdari | en |
| Author | Ali Ghane-Shahmirzadi | en |
| Author | Sezaneh Haghpanah | en |
| Author | Maral Mokhtari | en |
| Orcid | Nasrin Namdari [0000-0002-1597-8787] | en |
| Issued Date | 2025-11-30 | en |
| Abstract | Background: A high ferritin level in acute myeloid leukemia (AML) patients acts as a growth factor for leukemic cells, and its antioxidant effect may reduce the effectiveness of cytotoxic chemotherapy drugs, including anthracyclines. Methods: All adult patients with AML from 2013 to 2023, who had received 7+3 chemotherapy protocol at Namazi and Amir hospitals in Shiraz provided that Ferritin and C-reactive protein (CRP) level were checked before chemotherapy were included. We evaluated complete remission rate, overall survival (OS) and event-free survival (EFS) in 67 new cases. Results: The EFS was significantly longer in patients with serum ferritin levels below 1000 ng/mL compared to those with serum ferritin levels of 1000 ng/mL or higher [estimated mean and 95% CI: 25.65 (19.29 - 32) vs 11.6 (8.19 - 15.13) months, P = 0.018]. Conclusions: Ferritin levels at diagnosis are indicative of patient survival. The AML patients with serum ferritin levels greater than 1000 experienced shorter EFS compared to those with ferritin levels below 1000. | en |
| DOI | https://doi.org/10.5812/semj-161086 | en |
| Keyword | Ferritin | en |
| Keyword | 7+3 Regimen | en |
| Keyword | Allogeneic Stem Cell Transplantation | en |
| Keyword | Anthracycline | en |
| Publisher | Brieflands | en |
| Title | Effect of Serum Ferritin Level on the Response to Standard Chemotherapy in Acute Myeloid Leukemia Patients | en |
| Type | Research Article | en |
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