The Effect of Six Weeks-Voluntary Wheel Running on Brain Amyloid Beta (1-42) Levels of Diabetic Rats
| Author | Zia Fallah Mohammadi | en |
| Author | Mojtaba Ebrahimzadeh | en |
| Author | akbar hajizadeh moghaddam | en |
| Issued Date | 2013-05-31 | en |
| Abstract | Background : Amyloid Beta (1-42) is derived from amyloid precursor protein and plays a critical role in AD pathogenesis. The purpose of this study was to investigate the effect of 6 weeks of voluntary wheel running on brain Amyloid beta (1-42) in the diabetic rats induced with alloxan.Materials and Methods : 28 male rats weight 185±1 were assigned randomly to 4 groups (N=7): normal control (C), training (T), control-diabetic (CD) and diabetic-training (DT). Diabetes was induced with injecting Alloxan (120 mg/kg dissolved in saline) intraperitoneal.Results : 6 weeks of voluntary wheel running decreased the cortex Aβ1-42 in T and DT groups. Aβ1-42 levels significantly decreased in the T and DT in compare with C and CD (p | en |
| DOI | https://doi.org/ | en |
| Keyword | Aβ1-42 | en |
| Keyword | Voluntary wheel running | en |
| Keyword | Rats | en |
| Publisher | Brieflands | en |
| Title | The Effect of Six Weeks-Voluntary Wheel Running on Brain Amyloid Beta (1-42) Levels of Diabetic Rats | en |
| Type | Research Article | en |
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