Topical Sevoflurane: A Novel Treatment for Chronic Pain Caused by Venous Stasis Ulcers
| Author | Mayank Aranke | en |
| Author | Cynthia T Pham | en |
| Author | Melis Yilmaz | en |
| Author | Jason K Wang | en |
| Author | Vwaire Orhurhu | en |
| Author | Daniel An | en |
| Author | Elyse M. Cornett | en |
| Author | Alan David Kaye | en |
| Author | Anh L Ngo | en |
| Author | Farnad Imani | en |
| Author | Reza Farahmand Rad | en |
| Author | Giustino Varrassi | en |
| Author | Omar Viswanath | en |
| Author | Ivan Urits | en |
| Orcid | Elyse M. Cornett [0000-0001-7961-3931] | en |
| Orcid | Alan David Kaye [0000-0003-2464-0187] | en |
| Orcid | Farnad Imani [0000-0003-0814-0772] | en |
| Orcid | Reza Farahmand Rad [0000-0003-2783-6652] | en |
| Orcid | Giustino Varrassi [0000-0002-3822-2923] | en |
| Orcid | Omar Viswanath [0000-0002-6124-7037] | en |
| Orcid | Ivan Urits [0000-0002-3652-6085] | en |
| Issued Date | 2021-02-28 | en |
| Abstract | In the US, an estimated 1 - 2% of chronic venous insufficiency (CVI) patients (of 6 - 7 million nationwide) develop at least one venous stasis ulcer (VSU) during their illness. Of these, approximately 40% develop subsequent ulcers, making VSU prognostically poor. Current management of VSU is costly, with poor prognosis, high recurrence rate, inadequate pain management, and significantly reduced quality of life (QoL). Topical volatile anesthetic agents, such as sevoflurane, offer improved pain relief and symptom control in patients suffering from chronic VSU. The immediate impact of topical sevoflurane in reducing pain associated with ulcer bed debridement has several implications in improving the quality of life in patients with CVI induced ulcers and in the prognosis and healing of the ulcers. This review summarizes a topical formulation of a volatile anesthetic and its implications for the management of VSUs. | en |
| DOI | https://doi.org/10.5812/aapm.112832 | en |
| Keyword | Sevoflurane | en |
| Keyword | Venous Stasis Ulcer | en |
| Keyword | Pain | en |
| Keyword | Venous Insufficiency | en |
| Keyword | Analgesia | en |
| Keyword | Wound Management | en |
| Publisher | Brieflands | en |
| Title | Topical Sevoflurane: A Novel Treatment for Chronic Pain Caused by Venous Stasis Ulcers | en |
| Type | Review Article | en |
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