Effect of palmatine hydrochloride on testicular damage in streptozotocin-induced diabetic rats
| Author | Hamid Kalalianmoghaddam | en |
| Author | Vida Hojati | en |
| Author | Pirasteh Norouzi | en |
| Orcid | Vida Hojati [0000-0002-0408-389X] | en |
| Issued Date | 2017-07-31 | en |
| Abstract | Background: Diabetes mellitus mediated by oxidative stress, creates serious metabolic disorders in testis. Palmatine hydrochloride has various pharmacological effects, including anti-diabetic and antioxidant activities. Objective: This study has been conducted to evaluate the preventative effects of palmatine hydrochloride medicine on testicular damage in streptozotocin (STZ)-induced diabetic rats. Methods: Thirty two male Wistar rats were randomly selected and divided into four groups: control, non-diabetic treated with palmatine hydrochloride, diabetic and diabetic treated with palmatine hydrochloride. Diabetes was induced by streptozotocin (55 mg/kg, i.p.) in animals, and after one week, palmatine hydrochloride (10 mg/kg, s.c) was administered for six weeks in rats. Testicular damage was examined by using hematoxylin-eosin staining. Blood biochemical factors were measured. Findings: The results of this study indicate that diabetes reduced the spermatogonia and Sertoli cells, spermatogenesis, sperm count, and sperm function (P | en |
| DOI | https://doi.org/ | en |
| Keyword | Diabetes | en |
| Keyword | Palmatine | en |
| Keyword | Spermatogenesis | en |
| Keyword | Sertoli cells | en |
| Keyword | Testicular damage | en |
| Publisher | Brieflands | en |
| Title | Effect of palmatine hydrochloride on testicular damage in streptozotocin-induced diabetic rats | en |
| Type | Research Article | en |
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