Study of Mutations Associated with Isoniazid-Resistance in Clinical Mycobacterium Tuberculosis Strains, Tehran and Isfahan Province Tuberculosis Centers by PCR and RFLP-Based Technique (2004-5)

Abstract

Background & Objectives: Although isoniazid is the most efficient in killing the tuberculosis bacilli, resistance to this drug also develops most readily. Mutations in katG, inhA and ahpC are responsible for isoniazid resistance in a large proportion of tuberculosis cases. The frequency of these mutations varies with population samples, however. This study provided the first molecular characterization of Isoniazid-resistance in M. Tuberculosis strains that is widely applicable for rapid drug resistance detection.