Investigating the Effect of Vitamin D Administration on the Severity of Neuropathic Pain in Diabetic Patients of Dezful City in 2025
| Author | Malihe Moeinjozan | en |
| Author | Hamid Karimi | en |
| Author | Marjan Aliabdi | en |
| Author | Mansoureh Babadi | en |
| Orcid | Malihe Moeinjozan [0009-0001-5968-502X] | en |
| Orcid | Hamid Karimi [0000-0001-5527-4082] | en |
| Orcid | Marjan Aliabdi [0009-0005-1892-3502] | en |
| Orcid | Mansoureh Babadi [0000-0002-8907-1168] | en |
| Issued Date | 2024-11-30 | en |
| Abstract | Background: Type 2 diabetes mellitus (T2DM) is a complex metabolic disorder characterized not only by insulin resistance and hyperglycemia but also by chronic low-grade inflammation that profoundly affects the immune system. Moreover, clinical evidence suggests that vitamin D deficiency is strongly associated with increased risk and severity of diabetic peripheral neuropathy (DPN), while supplementation may alleviate neuropathic pain and improve nerve conduction. Objectives: This study aimed to evaluate the effect of vitamin D supplementation on the severity of neuropathic pain in diabetic patients in Dezful City in 2025. Methods: In this semi-experimental interventional study, the participants were selected based on the following inclusion criteria: Diagnosis of T2DM, confirmation of diabetic neuropathy using the Michigan screening tool and muscle nerve conduction assessment, serum vitamin D levels below 30 ng/mL, and willingness to participate. The sample size of 19 participants was determined using effect size estimates, based on a 0.05 type I error and 90% statistical power. To reduce bias and strengthen validity, a single-blind design was employed in this quasi-experimental study, with both participants and outcome assessors unaware of the specific study aim and intervention timing. According to baseline vitamin D levels, patients received one oral tablet of 50,000 IU vitamin D3 weekly for a period of 4 to 8 weeks. Neuropathy symptoms were evaluated before and after the intervention using the Michigan Neuropathy Screening Instrument (MNSI), which included both the questionnaire and the clinical examination. In addition, biochemical parameters such as serum vitamin D and HbA1c were measured at baseline and post-intervention. Quantitative data were expressed as mean ± standard deviation (SD), while qualitative data were reported as frequency (percentage). The Kolmogorov-Smirnov test was applied to assess the normality of data distribution. For normally distributed variables, paired t-tests were used, whereas the Wilcoxon signed-rank test was applied for non-normally distributed data. A P-value of Results: The study population (mean age 60.38 ± 10.38 years; 42.1% female, 57.9% male) demonstrated significant improvements following vitamin D supplementation. Serum vitamin D levels increased from 18.58 ± 5.97 to 35.03 ± 6.62 ng/mL (P < 0.001), while HbA1c decreased from 8.63 ± 1.13% to 7.81 ± 1.57% (P = 0.006). Neuropathy symptoms also improved significantly: Michigan Questionnaire scores decreased from 5.31 ± 1.05 to 3.47 ± 1.50, and clinical examination scores decreased from 5.50 ± 2.87 to 4.21 ± 2.19 (both P < 0.001). Patients reported reductions in numbness, burning pain, tingling, and hypersensitivity, alongside improved sensory function in the lower extremities. These improvements collectively suggest an enhanced quality of life. Conclusions: These findings suggest that vitamin D may serve as an adjunctive intervention in the management of type 2 diabetes by reducing inflammation and neuropathy while enhancing immune function. | en |
| DOI | https://doi.org/10.69107/jai-167087 | en |
| Keyword | Diabetes | en |
| Keyword | Neuropathy | en |
| Keyword | Vitamin D | en |
| Keyword | HbA1c | en |
| Keyword | Inflammation | en |
| Publisher | Brieflands | en |
| Title | Investigating the Effect of Vitamin D Administration on the Severity of Neuropathic Pain in Diabetic Patients of Dezful City in 2025 | en |
| Type | Research Article | en |
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