Time-Dependent Changes in the Magnetic Resonance Detection of Brain Metastases Using Single-Dose Gadobutrol
Author | Bing Fan |
Author | Mei-jiao Li |
Author | Xiao-ying Wang |
Author | Yu-feng Xu |
Author | Fei-yu Li |
Author | Lai-yun Zhang |
Author | Jian Jiang |
Author | Yan-yan Jiang |
Issued Date | 2018-01-31 |
Abstract | Objectives: The effect of delay in imaging on the assessment of contrast-enhanced magnetic resonance imaging (CE-MRI) has not been extensively studied. This study evaluated the effect of different delay times (3, 7, and 10 minutes) on gadobutrol (Gadovist)-enhanced MRI for diagnosis of brain metastases. Patients and Methods: This single-center, blind-reading, post-marketing study enrolled 52 patients with suspected or known brain metastases who received gadolinium-enhanced MR examinations. All the patients received 0.1 mmol/kg dose of gadobutrol, and serial axial T1 FLAIR images were obtained at each MR examination after a delay of 3, 7, and 10 minutes. The images were evaluated by two experienced radiologists independently. The evaluation included subjective and objective evaluations of the image quality. Results: Thirty-four patients were diagnosed with brain metastases. There were 295, 301, and 301 lesions detected in the 3, 7, and 10 minutes delay groups, respectively. Subjective evaluation revealed a higher mean quality score of lesion edge, lesion interior, and overall image quality in the 7 and 10 minutes groups compared to the 3 minutes group. Images in the 7- or 10-min delay groups had significantly greater CNR and CBR than the 3-min group (P < 0.05). Conclusion: A delay time of 7 minutes was considered optimal for imaging after gadobutrol administration in patients with brain metastases. |
DOI | https://doi.org/10.5812/iranjradiol.66054 |
Keyword | Gadobutrol |
Keyword | Magnetic Resonance Imaging |
Keyword | Brain Metastases |
Keyword | Delay Time |
Publisher | Brieflands |
Title | Time-Dependent Changes in the Magnetic Resonance Detection of Brain Metastases Using Single-Dose Gadobutrol |
Type | Research Article |