Time-Dependent Changes in the Magnetic Resonance Detection of Brain Metastases Using Single-Dose Gadobutrol
| Author | Bing Fan | en |
| Author | Mei-jiao Li | en |
| Author | Xiao-ying Wang | en |
| Author | Yu-feng Xu | en |
| Author | Fei-yu Li | en |
| Author | Lai-yun Zhang | en |
| Author | Jian Jiang | en |
| Author | Yan-yan Jiang | en |
| Issued Date | 2018-01-31 | en |
| Abstract | Objectives: The effect of delay in imaging on the assessment of contrast-enhanced magnetic resonance imaging (CE-MRI) has not been extensively studied. This study evaluated the effect of different delay times (3, 7, and 10 minutes) on gadobutrol (Gadovist)-enhanced MRI for diagnosis of brain metastases. Patients and Methods: This single-center, blind-reading, post-marketing study enrolled 52 patients with suspected or known brain metastases who received gadolinium-enhanced MR examinations. All the patients received 0.1 mmol/kg dose of gadobutrol, and serial axial T1 FLAIR images were obtained at each MR examination after a delay of 3, 7, and 10 minutes. The images were evaluated by two experienced radiologists independently. The evaluation included subjective and objective evaluations of the image quality. Results: Thirty-four patients were diagnosed with brain metastases. There were 295, 301, and 301 lesions detected in the 3, 7, and 10 minutes delay groups, respectively. Subjective evaluation revealed a higher mean quality score of lesion edge, lesion interior, and overall image quality in the 7 and 10 minutes groups compared to the 3 minutes group. Images in the 7- or 10-min delay groups had significantly greater CNR and CBR than the 3-min group (P < 0.05). Conclusion: A delay time of 7 minutes was considered optimal for imaging after gadobutrol administration in patients with brain metastases. | en |
| DOI | https://doi.org/10.5812/iranjradiol.66054 | en |
| Keyword | Gadobutrol | en |
| Keyword | Magnetic Resonance Imaging | en |
| Keyword | Brain Metastases | en |
| Keyword | Delay Time | en |
| Publisher | Brieflands | en |
| Title | Time-Dependent Changes in the Magnetic Resonance Detection of Brain Metastases Using Single-Dose Gadobutrol | en |
| Type | Research Article | en |