Desmopressin Lyophilisate for the Treatment of Central Diabetes Insipidus: First Experience in Very Young Infants
| Author | Kathleen De Waele | en |
| Author | Martine Cools | en |
| Author | Ann De Guchtenaere | en |
| Author | Johan Van de Walle | en |
| Author | Ann Raes | en |
| Author | Sara Van Aken | en |
| Author | Kris De Coen | en |
| Author | Piet Vanhaesebrouck | en |
| Author | Jean De Schepper | en |
| Issued Date | 2014-10-01 | en |
| Abstract | Introduction: In neonates and small infants, early diagnosis of central diabetes insipidus (CDI) and treatment with desmopressin in low doses (avoiding severe hypo- or hypernatremia) are important to prevent associated high morbidity and mortality in this particular age group. Case Presentetion: We described pharmacokinetic and pharmacodynamic results of the use of recently launched oral desmopressin lyophilisate (Minirin Melt®) in two infants with CDI, diagnosed at the age of 12 and 62 days, respectively. We observed that a starting dose of 60 μg of Minirin Melt® in the first case resulted in a pharmacokinetic profile largely exceeding the reference frame observed in children with nocturnal enuresis, while a dose of 15 μg in the second case resulted in acceptable concentrations. After initial dose adjustments, administration of sublingual lyophilisate resulted in rather stable serum sodium concentrations. Conclusions: Using Minirin Melt® in infants with CDI appears to be effective, easy to use and well tolerated. | en |
| DOI | https://doi.org/10.5812/ijem.16120 | en |
| Keyword | Desmopressin | en |
| Keyword | Diabetes Insipidus | en |
| Keyword | Infant | en |
| Keyword | Hypernatremia | en |
| Publisher | Brieflands | en |
| Title | Desmopressin Lyophilisate for the Treatment of Central Diabetes Insipidus: First Experience in Very Young Infants | en |
| Type | Case Report | en |
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