Modulation of microRNA-133B in Post Mastectomy Pain Syndrome Following Yoga Intervention
| Author | Ashok K Saxena | en |
| Author | Prakash Gondode | en |
| Author | Geetanjali T Chilkoti | en |
| Author | Tusha Sharma | en |
| Author | Basu D Banerjee | en |
| Issued Date | 2024-06-30 | en |
| Abstract | Objectives: This study aimed to compare the efficacy of yoga combined with an integrated multimodal approach on the incidence and severity of post-mastectomy pain syndrome (PMPS) and the role of miR-133B expressions in patients undergoing breast cancer surgery. Methods: With approval from the institutional ethics committee and informed consent obtained from each participant, forty patients of ASA grade I - II, aged 20 - 65 years, undergoing breast cancer surgery were included. Patients received a thoracic paravertebral block for up to 72 hours and pregabalin until the end of the fourth postoperative week. Patients were randomly allocated into two groups: “Control” and “yoga.” Patients in the Yoga group practiced the yogic exercise “Anulom-vilom" from the third day until the 90th day postoperatively. The delta-CT of miRNA-133B expression of genes on the 90th postoperative day was compared to the baseline, along with various pain intensity and quality of life parameters. Results: In the Yoga group, a significant up-regulation in miR-133B expression was observed on days 30 and 90 postoperatively. Patients with PMPS in the Yoga group showed a decreased ΔCT of miR-133B, indicating an up-regulation of gene expression, compared to the control group. A lower incidence of PMPS (10% vs. 30%) was observed in the experimental group, along with a significant enhancement of quality of life in post-mastectomy patients and decreased mean Visual Analogue Scale (VAS) pain scores, Pain Detect Questionnaire (PDQ) ، and Neuropathic Pain Symptom Inventory (NPSI) scores in the Yoga group; however, these were not statistically significant. Conclusions: The study demonstrated the feasibility of integrating yoga with a multimodal pain management approach and highlighted the role of miR-133B in the pathogenesis of PMPS. | en |
| DOI | https://doi.org/10.5812/jcma-146528 | en |
| Keyword | Anuloma Vilom | en |
| Keyword | Chronic Pain | en |
| Keyword | Micro RNA | en |
| Keyword | miR-133B | en |
| Keyword | Neuropathic Pain | en |
| Keyword | Post Mastectomy Pain Syndrome | en |
| Keyword | Quality of Life | en |
| Keyword | Yoga | en |
| Publisher | Brieflands | en |
| Title | Modulation of microRNA-133B in Post Mastectomy Pain Syndrome Following Yoga Intervention | en |
| Type | Research Article | en |
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