Association of the Effect of SLC6A4 Gene Polymorphisms on the Risk of Diabetes‏

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Context: The SLC6A4 gene encodes the serotonin transporter. Mutations in this gene can lead to various diseases, such as diabetes. Diabetes is one of the most common metabolic disorders with a genetic background. This review study evaluated the role of SLC6A4 gene polymorphisms in the risk of diabetes. Evidence Acquisition: In this review article, a literature search was conducted in scientific databases, including Google Scholar and PubMed, to find studies published within 2000 to 2021 on the role of SLC6A4 gene polymorphisms on the risk of diabetes. Results: Some genetic and environmental factors are involved in the development of diabetes. Additionally, the association between diabetes and disorder in different genes has been investigated in numerous studies. The discovery of these genetic changes in diabetes might shed light on the functional role of genetic mutations in the development of diabetes. Conclusions: Further genomic research is needed to determine the possible role of SLC6A4 gene polymorphisms in diabetes and obesity.