Acid-base Homeostasis in Children With Growth Hormone Deficiency
| Author | Z Karamizadeh | en |
| Author | Mohammad Amin Kashef | en |
| Author | G Amirhakimi | en |
| Author | N Ghaemi | en |
| Issued Date | 2006-10-31 | en |
| Abstract | To determine whether children with growth hormone deficiency (GHD) have lower mean serum bicarbonate concentrations than do children with short stature due to other causes. Materials and Methods: We evaluated one hundred short stature children, aged 5 to 15 years, attending the children's endocrine clinic at Motahari clinic, Shiraz, Iran, over a 6 month period. Demographic data and clinical features were recorded, laboratory investigations were performed, and bone ages were calculated. GHD was defined as serum GH concentration )10 ng/ml in response to L-dopa and clonidine, in addition a thorough work-up was performed to exclude any other known clinical conditions that might lead to growth retardation. Results: Thirty one patients (31%) had GHD, 69 (69%) were not GH deficient, and one case had panhypopituitarism. Serum bicarbonate concentrations were significantly lower in GHD compared with non-GHD patients (15.68±2.79 versus 17.98±3.79 mEq/l, P=0.003). On the other hand, 52 (75%) GHD subjects and 22 (71%) non-GHD had arterial blood pH values below 7.35, the difference not being statistically significant. All GHD patients had abnormal serum bicarbonate levels versus 87% of non-GHD cases (P | en |
| DOI | https://doi.org/ | en |
| Keyword | Growth hormone | en |
| Keyword | Serum bicarbonate | en |
| Keyword | Short stature | en |
| Keyword | Acid-base homeostasis | en |
| Publisher | Brieflands | en |
| Title | Acid-base Homeostasis in Children With Growth Hormone Deficiency | en |
| Type | Research Article | en |
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