Negative Correlation of Interleukin-38 Serum Level with Alkaline Phosphatase and Persistent Hepatitis C Infection
| Author | Najmeh Rokhtabnak | en |
| Author | Mohammad Reza Ataollahi | en |
| Author | Morvarid Asadipour | en |
| Author | Mohammad Ali-Hassanzadeh | en |
| Author | Pooria Fazeli | en |
| Author | Soolmaz Khansalar | en |
| Author | Esmaeel Ghani | en |
| Author | Kurosh Kalantar | en |
| Issued Date | 2022-09-30 | en |
| Abstract | Background: Hepatitis C virus (HCV) is the main cause of acute and chronic liver failure. It seems that interleukin-38 (IL-38), a member of IL-1 cytokine family, has an anti-inflammatory function through binding to the receptor of several cytokines. Objectives: To examine serum level of IL-38 in HCV-infected patients and its correlation with liver enzymes. Methods: We measured serum levels of IL-38 and liver enzymes in 26 untreated and 11 treated HCV-infected patients and 26 healthy individuals using ELISA and biochemistry assay kits, respectively. Results: Serum level of IL-38 was significantly lower in untreated HCV+ patients compared to treated patients (P = 0.014) and control group (P < 0.0001). In addition, IL-38 levels negatively correlated with alkaline phosphatase (ALP) levels in untreated HCV+ patients (r = -0.905, P = 0.042). However, no significant correlations were detected between serum levels of IL-38 and other liver enzymes. Conclusions: Our results suggest a potential anti-inflammatory role for IL-38 in chronic HCV infection which can be implemented to prevent severe hepatic failure in patients with hepatitis C. | en |
| DOI | https://doi.org/10.5812/semj-121969 | en |
| Keyword | Hepatitis C Virus | en |
| Keyword | IL-38 | en |
| Keyword | Anti-inflammatory | en |
| Keyword | Liver Enzymes | en |
| Keyword | Alkaline Phosphatase (ALP) | en |
| Publisher | Brieflands | en |
| Title | Negative Correlation of Interleukin-38 Serum Level with Alkaline Phosphatase and Persistent Hepatitis C Infection | en |
| Type | Research Article | en |
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