Effects of treadmill exercise and preconditioned bone marrow- derived mesenchymal stem cells transplantation on Aβ-induced neurotoxicity in male rats
| Author | Rokhsareh Abshenas | en |
| Author | tayebeh artimani | en |
| Author | Iraj Amiri | en |
| Author | Siamak Shahidi | en |
| Author | Rezvan Najafi | en |
| Author | Sara soleimani asl | en |
| Issued Date | 2020-06-30 | en |
| Abstract | Introduction: Preconditioning of mesenchymal stem cells (MSCs) is a promising strategy to enhance the therapeutic properties of transplanted MSCs. In this study, we investigated the synergistic effects of treadmill exercise and dimethyloxalylglycine (DMOG)-preconditioned stem cells in an Alzheimer’s disease (AD) model. Materials and Methods: DMOG- treated MSCs were intravenously transplanted in the AD model and the rats went on treadmill exercise for one month. Thusly, expression of bax, bcl-2, Nrf2, and NQO1 genes were assessed using real- time PCR. Results: Transplantation of DMOG-treated cells had greater effects on increasing Nrf-2 and NQ1 expression and reducing apoptosis compared to non- treated cells. Ultimately, treadmill exercises for one month along with the transplantation of DMOG- treated cells showed the highest neuroprotective effect. Conclusion: It seems that the transplantation of DMOG-treated cells beside exercise may have protective effects in the AD model via an increase in antioxidant capacity and a decrease in apoptosis. | en |
| DOI | https://doi.org/ | en |
| Keyword | Exercise | en |
| Keyword | Amyloid | en |
| Keyword | Mesenchymal Stem cells | en |
| Keyword | Oxalylglycine | en |
| Keyword | Antioxidant | en |
| Keyword | Apoptosis | en |
| Keyword | ورزش | en |
| Keyword | آمیلوئید | en |
| Keyword | سلولهای بنیادی مزانشیمی | en |
| Keyword | اگزالیل گلیسین | en |
| Keyword | آنتیاکسیدانها | en |
| Keyword | آپپتوزیس | en |
| Publisher | Brieflands | en |
| Title | Effects of treadmill exercise and preconditioned bone marrow- derived mesenchymal stem cells transplantation on Aβ-induced neurotoxicity in male rats | en |
| Type | Research Article | en |