Human Umbilical Cord Mesenchymal Stem Cells-Derived Exosomes Can Alleviate the Proctitis Model Through TLR4/NF-Kb Pathway
| Author | Zahra Ebrahim Soltani | en |
| Author | Mohammad Elahi | en |
| Author | Hasti Tashak-Golroudbari | en |
| Author | Abolfazl Badripour | en |
| Author | Hojjatollah Nazari | en |
| Author | Asieh Heirani-Tabasi | en |
| Author | Reza Akbari Asbagh | en |
| Author | Mohammad Amin Dabbagh Ohadi | en |
| Author | Moojan Shabani | en |
| Author | Mina Mahboudi | en |
| Author | Mojdeh Sarzaeim | en |
| Author | alireza mahdavi | en |
| Author | Behnam Behboudi | en |
| Author | Mohammad Reza Keramati | en |
| Author | Alireza Kazemeini | en |
| Author | Seyed Mohsen Ahmadi Tafti | en |
| Issued Date | 2023-12-31 | en |
| Abstract | Background: Proctitis is a significant concern of inflammatory bowel diseases, especially ulcerative colitis. Exosomes are a new method for treating many diseases by their immunosuppressive and tissue-repairing potential. Here, we tried Mesenchymal stem cells (MSCs)-derived Exosomes for treating the proctitis model of rats. Materials and Methods: Rats were assigned into four groups: sham, control group, rectal, and intraperitoneal exosome injection. The proctitis model was induced by rectal administration of 4% acetic acid. The exosome was derived from human MSCs isolated from human umbilical cords. After seven days, rectum samples were assessed for histopathological, IHC, and PCR analysis. Results: The histopathologic scores, collagen deposition, and the expression of NF-?B, TLR4, TNF?, IL-6, and TGF? were decreased in intraperitoneal exosome compared to controls. The result was not promising for the rectal administration of exosomes. Conclusion: Exosomes can suppress the inflammatory response in the proctitis model and improve the rectum's healing process. Exosomes can inhabit the NF-?B/TLR4 pathway and downstream pro-inflammatory cytokines. This study implicates the therapeutic benefits of exomes in treating proctitis. | en |
| DOI | https://doi.org/10.22037/jcma.v8i4.41127 | en |
| Keyword | Exosome; mesenchymal stem cells; proctitis; inflammatory bowel disease | en |
| Publisher | Brieflands | en |
| Title | Human Umbilical Cord Mesenchymal Stem Cells-Derived Exosomes Can Alleviate the Proctitis Model Through TLR4/NF-Kb Pathway | en |
| Type | Original Articles | en |
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