Protective role of vitamin-D on chronic stress induced-learning and memory deficits in rats
| Author | Sara Choobdar | en |
| Author | Abbas-Ali Vafaei | en |
| Author | A. li Rashidy-Pour | en |
| Author | Katayoun Sedaghat | en |
| Orcid | Katayoun Sedaghat [0000-0001-5424-8640] | en |
| Issued Date | 2019-12-31 | en |
| Abstract | Introduction: Long-term stress disturbs HPA axis and increases glucocorticoids release, which disturbs neural plasticity in the hippocampus and may lead to learning and memory deficits. Noticeably, vitamin D plays a protective role in the nervous system and has receptors in the hippocampus. This behavioral study investigates the possible protective role of vitamin-D against the negative effects of chronic stress on learning and memory. Materials and Methods: All the Rats were randomly divided to two groups stress and control groups (each had 3 subgroups). Stress-group animals were exposed to restraint stress for 28 days, 3 hours/day. During 28 days, vitamin D (5 or 10 mg/kg), or vehicle was injected (IP) twice weekly to both groups. At day 29, blood sample collected for serum corticosterone assay. Morris water maze (MWM) test was performed in the order of 4 days training, one-day probe testing and finally working memory test. Passive avoidance test was performed after MWM. Results: Stress group revealed higher levels of serum corticosterone (P | en |
| DOI | https://doi.org/ | en |
| Keyword | Chronic Limiting Stress | en |
| Keyword | Hippocampus | en |
| Keyword | Memory | en |
| Keyword | Learning | en |
| Keyword | Vitamin D | en |
| Keyword | Corticosterone | en |
| Keyword | Morris Water Maze | en |
| Keyword | Passive-avoidance Test | en |
| Keyword | استرس محدودکننده | en |
| Keyword | ویتامین D | en |
| Keyword | موش صحرایی | en |
| Keyword | آزمون احترازی غیر فعال | en |
| Keyword | کورتیکوسترون | en |
| Keyword | ماز آبی موریس | en |
| Publisher | Brieflands | en |
| Title | Protective role of vitamin-D on chronic stress induced-learning and memory deficits in rats | en |
| Type | Research Article | en |