Serum Level of GDNF is Associated with Adherence to Methadone Maintenance Treatment
| Author | Aida Afghani | en |
| Author | Emran M Razaghi | en |
| Author | Reza Rastgoo Sisakht | en |
| Author | Ali Farhoudian | en |
| Author | Nasim Vousooghi | en |
| Orcid | Ali Farhoudian [0000-0002-8784-522X] | en |
| Orcid | Nasim Vousooghi [0000-0002-3392-3640] | en |
| Issued Date | 2023-07-31 | en |
| Abstract | Background: Preclinical studies have shown that neurotrophic factors, including brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF), are involved in the modulation of biochemical and behavioral adaptations to substance use. Methods: We studied the impact of GDNF and BDNF serum levels on adherence to methadone maintenance treatment (MMT) through cross-sectional research. Participants were clients on MMT (43 males), subjects in remission from opioid use disorder (12 males), and healthy controls (20 males). Adherence and non-adherence to treatment were assessed by the detection of illicit opioids in random urinalysis. Results: Using t-tests for independent groups and analysis of variance (ANOVA), GDNF serum levels in the adherent patients to MMT were found to be significantly higher than in the non-adherent patients. BDNF serum levels were not different between adherent and non-adherent patients. Conclusions: Our results suggest the involvement of GDNF as a biological factor in adherence to MMT. | en |
| DOI | https://doi.org/10.5812/ans-139049 | en |
| Keyword | GDNF | en |
| Keyword | BDNF | en |
| Keyword | Adherence to Treatment | en |
| Keyword | MMT | en |
| Keyword | Heroin Use Disorder | en |
| Publisher | Brieflands | en |
| Title | Serum Level of GDNF is Associated with Adherence to Methadone Maintenance Treatment | en |
| Type | Research Article | en |
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