Comparison of Intraoperative Infusion of Remifentanil Versus Fentanyl on Pain Management in Patients Undergoing Spine Surgery: A Double Blinded Randomized Clinical Trial
| Author | Reza Shariat Moharari | en |
| Author | Shervin Shahinpour | en |
| Author | Negin Saeedi | en |
| Author | Elaheh Sahraei | en |
| Author | Atabak Najafi | en |
| Author | Farhad Etezadi | en |
| Author | Mohamadreza Khajavi | en |
| Author | Ayat Ahmadi | en |
| Author | Pejman Pourfakhr | en |
| Orcid | Reza Shariat Moharari [0000-0003-3398-896X] | en |
| Orcid | Shervin Shahinpour [0000-0003-0997-4197] | en |
| Orcid | Atabak Najafi [0000-0002-1663-9533] | en |
| Orcid | Farhad Etezadi [0000-0002-3437-6431] | en |
| Orcid | Mohamadreza Khajavi [0000-0002-4759-8551] | en |
| Orcid | Pejman Pourfakhr [0000-0003-4071-5900] | en |
| Issued Date | 2021-08-31 | en |
| Abstract | Background: Remifentanil is an ultra-short-acting opioid which facilitates hemodynamic management. However, there are concerns about postoperative Remifentanil hyperalgesia because of its potent fast onset and offset. Objectives: The aim of this study was to determine visual analog scale (VAS), postoperative pain, and morphine used in two groups after spine surgery. Methods: In this randomized clinical trial study, 60 patients aged 18 - 60 years old, according to the American Society of Anesthesiology (ASA) I - II, who underwent spinal canal stenosis or scoliosis surgery, were divided into two groups. In the control group, patients received 0.07 - 0.1 µg/kg/h intraoperative Fentanyl infusion, and in the intervention group 0.1 - 0.2 µg/kg/min remifentanil was infused during the surgery. Both groups received 15 mg/kg intravenous Acetaminophen 20 minutes before the end of the surgery. Postoperative pain score and morphine consumption were measured 6, 12, 24, and 48 hours after discharge from the post-anesthesia care unit (PACU). Results: During the first 12 hours, VAS and morphine consumption were significantly higher in remifentanil group (P < 0.001). However, no significant difference was found between the two groups in morphine consumption 12 - 48 hours after surgery. Conclusions: These findings suggest that Remifentanil infusion during surgery may increase postoperative pain. Also, VAS and morphine consumption were higher during the first 12 hours. | en |
| DOI | https://doi.org/10.5812/aapm.115576 | en |
| Keyword | Remifentanil | en |
| Keyword | Fentanyl | en |
| Keyword | Postoperative pain | en |
| Keyword | Spine surgery | en |
| Publisher | Brieflands | en |
| Title | Comparison of Intraoperative Infusion of Remifentanil Versus Fentanyl on Pain Management in Patients Undergoing Spine Surgery: A Double Blinded Randomized Clinical Trial | en |
| Type | Research Article | en |
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