Role of COVID-19 in Hepatic Damage and Its Cellular Entrance and Mechanism of Action: A Mini-Review
| Author | Ali Akbar Oroojan | en |
| Orcid | Ali Akbar Oroojan [0000-0001-5249-3239] | en |
| Issued Date | 2021-02-28 | en |
| Abstract | Context: COVID-19 induces damage to the liver in addition to the pulmonary system. This event can alter hepatic biochemical and histological variables. Therefore, the present mini-review study investigated the effect of COVID-19 on hepatic damages and its cellular mechanism of action. Evidence Acquisition: In this mini-review study, the effects of COVID-19 on liver cells were sought in PubMed without restriction. The related components were searched in the Me SH term system and also used in two groups of COVID-19 and hepatocytes in combination with each other. Then, the titles and abstracts of the selected articles were assessed, and unrelated articles were removed. Results and Conclusion: COVID-19 leads to liver tissue damage and hepatocyte apoptosis by inducing increased cytokines, ischemia, and hepatic hypoxia following cardiorespiratory failure, coagulation disorders, and intracellular calcium. The SARS-CoV-2 virus exerts this effect through the ACE2 receptor and increasing its expression in cholangiocytes. | en |
| DOI | https://doi.org/10.5812/tms.113644 | en |
| Keyword | COVID-19 | en |
| Keyword | SARS-CoV-2 | en |
| Keyword | Liver | en |
| Keyword | Hepatocyte | en |
| Publisher | Brieflands | en |
| Title | Role of COVID-19 in Hepatic Damage and Its Cellular Entrance and Mechanism of Action: A Mini-Review | en |
| Type | Review Article | en |