A Comparative Study of Intravenous Infusion of Ketamine-Propofol and Ketamine-Dexmedetomidine for Deep Sedation and Analgesia in Pediatric Patients Undergoing Day Care Surgeries at Niloufer Hospital

Abstract

Background: to compare intravenous infusion of ketamine-propofol and ketamine-dexmedetomidine for deep sedation and analgesia in pediatric patients.Materials and Methods: A total of 60 children aged 3-12 were divided into two groups, to receive drug dosage of Ketamine 2mg/kg and propofol 2 mg/kg IV. In group KP (Ketamine + Propofol) and 2mg/kg ketamine injection; also 1?g/kg dexmedetomidine for group KD (Ketamine + dexmedetomidine). In both groups, hemodynamic changes (MAP, Heart rate, and SpO2), pain, and sedation were assessed intraoperatively at 5, 10, 15, 20, and 30 minutes and post-operatively at 5, 10, 15, 30, and 60 minutes up to 6 hours. Both groups were similar in age distribution and weight from 9-30 Kg. Results: Preoperative heart rate, mean arterial pressure, and SpO2 were statistically insignificant (P>0.05). MAP levels intraoperatively and postoperatively were higher in the KP group. Heart rates were lower in the KD group. Postoperatively pain scores were less in the KD group. Intraoperatively, sedation scores were similar in both groups. Conclusion: the ketamine-propofol group had stable intra and post-operative hemodynamic parameters and early recovery scores.