APOE and CPT1-A Promoter Methylation and Expression Profiles in Patients with Schizophrenia
| Author | Dor Mohammad Kordi-Tamandani | en |
| Author | Maryam Najafi | en |
| Author | Azizall Mojahad | en |
| Orcid | Dor Mohammad Kordi-Tamandani [0000-0001-7727-3814] | en |
| Issued Date | 2014-04-01 | en |
| Abstract | Background: Apo-lipoprotein E (APOE) and Carnitine palmitoyltransferase1-A (CPT1-A) genes are well known to be involved in the pathophysiology of psychiatric disorders such as schizophrenia but regarding their CPG island methylation status data is sparse. Objectives: The aims of the current study were to highlight the effect of the promoter “hypermethylation” in the development of SCZ. Patients and Methods: Genomic DNA was extracted from peripheral blood of 80 patients with schizophrenia and 71 healthy controls. The Methylation pattern was studied using Methylation-Specific PCR. RNA expression analysis was performed on extracted RNA from blood samples of patients suffering from schizophrenia (n = 17) and healthy controls (n = 17). Results: Frequency of the APOE and CPT1-A methylation show insignificant relationship between cases and controls. Estimates of relative gene expression revealed no significant statistical association of the APOE and CPT1-A genes between schizophrenic patients and healthy controls. Conclusions: This is the first evidence regarding APOE and CPT1-A gene methylation and their expression profile related to risk of schizophrenia which indicate no significant association between the APOE and CPT1-A gene methylation and development of schizophrenia. | en |
| DOI | https://doi.org/10.17795/gct-18359 | en |
| Keyword | Apolipoproteins E | en |
| Keyword | carnitine palmitoyltransferase 1A | en |
| Keyword | human | en |
| Keyword | Schizophrenia | en |
| Publisher | Brieflands | en |
| Title | APOE and CPT1-A Promoter Methylation and Expression Profiles in Patients with Schizophrenia | en |
| Type | Research Article | en |
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