Magnetic Resonance Spectroscopy of Brain Circuits in Patients with First-Episode Obsessive-Compulsive Disorder
| Author | Feng Chen | en |
| Author | Min Guo | en |
| Author | Tao Liu | en |
| Author | Xiang Ling Jiang | en |
| Author | Jian Jun Li | en |
| Author | Jun Cheng Guo | en |
| Issued Date | 2017-01-31 | en |
| Abstract | Background: Obsessive-compulsive disorder (OCD) is considered neurodevelopmental disorder that shares the feature of dysfunctional frontal-subcortical circuitry, yet the relationship between structural abnormalities or neurobiochemistrical changes and OCD pathogenesis is still unknown. Objectives: This study aims to use magnetic resonance spectroscopy (MRS) to discover substance-metabolism abnormalities of brain circuits in patients with first-episode OCD, and to study the mechanism of OCD. Patients and Methods: Twenty patients with first-episode OCD and twenty gender- and age-matched normal controls were studied. Neurochemical abnormalities, including ratios of N-acetylaspartate (NAA), creatine (Cr), and choline (Cho), were measured in the prefrontal cortex, anterior cingulate cortex, orbitofrontal cortex, caudate nucleus, and thalamus with three-dimensional 1H-proton MRS (3D 1H-MRS). The data of the ratios in the two groups were analyzed with a independent samples t-test. Results: Cho/Cr ratios in the thalamus were significantly higher in the first-episode OCD patients than in the controls (P < 0.01), and the NAA/Cr ratios in the caudate nucleus and thalamus were significantly lower in the first-episode OCD patients than in the controls (P < 0.01). However, NAA/Cr ratios in the anterior cingulate cortex and orbitofrontal cortex were higher in the first-episode OCD patients than in the controls (P < 0.01). Conclusion: Distinct neurochemical and histological structure changes (cortico-striatal-thalamic-cortical cycle) exist in patients with first-episode OCD. 1H-MRS is capable of identifying these changes by assessing metabolic abnormalities. | en |
| DOI | https://doi.org/10.5812/iranjradiol.15566 | en |
| Keyword | Obsessive-Compulsive Disorder | en |
| Keyword | Brain | en |
| Keyword | Magnetic Resonance Spectroscopy | en |
| Publisher | Brieflands | en |
| Title | Magnetic Resonance Spectroscopy of Brain Circuits in Patients with First-Episode Obsessive-Compulsive Disorder | en |
| Type | Research Article | en |
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