Study of Antibacterial Effect of Novel Thiazole, Imidazole, and Tetrahydropyrimidine Derivatives against Listeria Monocytogenes

Abstract

Purpose: In this study, we have focused on antibacterial effect of newly synthesized thiazole, imidazole, and tetrahydropyrimidine derivatives in Iran on listeria monocytogenes. Materials and Methods: For evaluation of antibacterial effect, the disk diffusion method was applied to measure the growth inhibition zone diameter and broth micro dilution was performed to determine the minimum inhibitory concentration. Results: Assessing the antibacterial effect showed that only thiazole derivative 6d had inhibitory effect on listeria monocytogenes and the other thiazole, imidazole and tetrahydropyrimidine derivatives lacked any inhibitory clue on this organism. The inhibitory effect of thiazole derivative 6d was shown by minimum inhibitory concentration = 64 and growth inhibition zone diameter = 23 ± 0.1. In antibiogram test, also the most susceptibility was recorded for gentamicin and penicillin with minimum inhibitory concentration = 1 µg/mL. Conclusion: The antibacterial effect of thiazole, imidazole and tetrahydropyrimidine derivatives differs from each other and cross connections such as linkage of oxygen to thiazole ring in derivative 6d, could reinforce this effect. By proving the in vitro antibacterial effect of the novel thiazole derivative on listeria monocytogenes, to more recognize this compound, next step is determining the toxicity and therapeutic effects in laboratory animals.