Antidepressant Effect of Hydroalcoholic Extract of Quercus Brantii and Oil of Quercus Brantii on a Rat Model of Postpartum Depression
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Date
2024-02-29
0000-0003-3748-382X Journal Title
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Volume Title
Publisher
Brieflands
Abstract
Background and Objectives: One of the most common complications after childbirth is postpartum depression (PPD), a major depressive disorder. The aim of this study was to investigate the effects of the hydroalcoholic extract and oil of Quercus brantii as an experimental model of PPD in rats. Subjects and Methods: 42 adult female Wistar rats in six groups were used in this study. All animals received daily progesterone injections at a dose of 5 mg/kg intraperitoneally for 5 consecutive days. A hydroalcoholic extract of Quercus brantii (100mg/kg) and oil (45%) were administered simultaneously with PPD modeling by progesterone withdrawal. On day 8, depressive behavior was then assessed by a forced swim test. To investigate the role of the oxidant-antioxidant system, reduced glutathione (GSH), catalase, superoxide dismutase (SOD) and malondialdehyde (MDA) have been assessed after the last injection. Results: Statistical analysis showed that progesterone induced significant immobilization in the control group receiving saline (P