Serum Cystatin C as a Marker of Renal Function in Critically Ill Patients With Normal Serum Creatinine
| Author | Mohammad Mahdi Sagheb | en |
| Author | Soha Namazi | en |
| Author | Bita Geramizadeh | en |
| Author | Amin Karimzadeh | en |
| Author | Mohammad Bagher Oghazian | en |
| Author | Iman Karimzadeh | en |
| Orcid | Iman Karimzadeh [0000-0002-8956-4528] | en |
| Issued Date | 2014-03-01 | en |
| Abstract | Background: Serum creatinine as a classic marker of renal function has several limitations in the detection of renal dysfunction. Objectives: This study assessed the validity of serum cystatin C as a marker of renal function in critically ill patients with normal serum creatinine. Patients and Methods: Eighty adult patients referred to intensive care units with serum creatinine levels < 1.5 mg/dL and without hemodynamic instability were chosen and their serum creatinine and cystatin C levels were measured. A 24-hour urine sample was collected to calculate creatinine clearance (Ccr). Renal dysfunction was defined as Ccr < 80 mL/min/1.73 m2. Results: There were significant correlations between measured Ccr and 1/serum creatinine (R = 0.51, P < 0.001) and 1/serum cystatin C (R = 0.25, P = 0.028). The difference between false negative rates of serum creatinine (93.33%) and cystatin C (80%) in the detection of renal dysfunction was significant (P = 0.032). Receiver operating characteristic curve analysis illustrated that area under the curve of serum creatinine and cystatin C for detecting renal dysfunction were 0.711 and 0.607, respectively; however, this difference was not significant (P = 0.222). Conclusions: Our data demonstrated that serum cystatin C is not superior to serum creatinine in the early detection of renal dysfunction in critically ill patients. | en |
| DOI | https://doi.org/10.5812/numonthly.15224 | en |
| Keyword | Critically Ill | en |
| Keyword | Patients | en |
| Keyword | Creatinine | en |
| Keyword | Cystatin C | en |
| Keyword | Acute Kidney Injury | en |
| Publisher | Brieflands | en |
| Title | Serum Cystatin C as a Marker of Renal Function in Critically Ill Patients With Normal Serum Creatinine | en |
| Type | Research Article | en |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- 17107-pdf.pdf
- Size:
- 205.37 KB
- Format:
- Adobe Portable Document Format
- Description:
- Article/s PDF