Associations of Ki-67 Labeling Index with Clinical and Paraclinical Features of Growth Hormone-Secreting Pituitary Adenomas: A Single Center Report from Iran
| Author | Shahrzad Mohseni | en |
| Author | Maryam Aboeerad | en |
| Author | Farshad Sharifi | en |
| Author | Seyed Mohammad Tavangar | en |
| Author | Mohammadreza Mohajeri-Tehrani | en |
| Orcid | Farshad Sharifi [0000-0002-2035-6587] | en |
| Orcid | Seyed Mohammad Tavangar [0000-0002-4253-2385] | en |
| Issued Date | 2019-04-30 | en |
| Abstract | Background: Acromegaly is a rare disorder resulting from benign growth hormone (GH)-secreting pituitary adenomas in 90% of the cases. In recent years, many researchers have studied the Ki-67 index level of pituitary tumors and its relationship with demographics, biochemical parameters, clinical behavior, and recurrence rate. Objectives: This study aimed to evaluate the correlation of Ki-67 index level with clinicoradiological and endocrinological parameters in confirmed GH-secreting pituitary adenomas, as well as with the surgical response and medical treatment after surgery. Methods: We collected the medical and pathologic records of 49 patients with GH-secreting pituitary adenoma who underwent surgeries from 2008 to 2017 in Shariati hospital affiliated to Tehran University of Medical Sciences. Results: According to MRI reports, 94% of the tumors were macroadenomas. The MRI findings also revealed the median maximal adenoma diameter of 18.5 mm. About 40% of the patients achieved remission three months after the surgery. Younger patients had a significantly higher Ki-67 index level (P = 0.036). We did not observe any significant difference in the Ki-67 index level regarding gender, tumor type, maximal tumor diameter, tumor invasiveness, tumor secretory type, and remission. Interestingly, the Ki-67 index level was negatively correlated with the insulin-like growth factor-1 (IGF-1) level at the last follow-up (P = 0.02). In logistic regression analysis, patients with higher preoperative GH serum levels had a better outcome. Conclusions: Our results indicated a negative correlation between age and Ki-67 index level. However, there was no association between the Ki-67 index level and some tumor behaviors, as well as short- and long-term remission. | en |
| DOI | https://doi.org/10.5812/ijem.81983 | en |
| Keyword | Acromegaly | en |
| Keyword | Growth Hormone | en |
| Keyword | Ki-67 | en |
| Keyword | Surgery | en |
| Publisher | Brieflands | en |
| Title | Associations of Ki-67 Labeling Index with Clinical and Paraclinical Features of Growth Hormone-Secreting Pituitary Adenomas: A Single Center Report from Iran | en |
| Type | Research Article | en |
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