Chromosomal Abnormalities Through Amniocentesis

Abstract

Objectives: The study aimed to assess the frequency and type of abnormal karyotype in Khuzestan, Iran by amniocentesis before 22 weeks of gestation. Methods: We conducted a retrospective analysis of 1197 amniotic fluid specimens in Khuzestan province, before 22 weeks gestations for fetal karyotyping. Results: The incidence of abnormal aneuploidies was 4.9% (59 of 1197) for all specimens. The highest chromosomal abnormality was Down syndrome (64.4%). Conclusions: The rate of chromosomal abnormalities was higher than other reports from Iran and all over the world. The detection rate of Down syndrome similar to other reports remains high.