Differential Responses to Acarbose Between Obese and Non-obese Patients with Type 2 Diabetes Mellitus
| Author | Chou Chien-Wen | en |
| Author | Ou Horng-Yih | en |
| Author | Hsiao Shu-Hwa | en |
| Author | Wu Ta-Jen | en |
| Issued Date | 2006-04-30 | en |
| Abstract | To investigate the responses in terms of body weight, glycemic control, metabolic control, and the side effects to acarbose add-on therapy in obese and non-obese type 2 diabetes patients with inadequately controlled by sulfonylureas and metformin. Materials and Methods: Forty obese (BMI≤ 27) and 80 sex- and age-matched non-obese patients with type 2 diabetes mellitus were enrolled in this 3-month, open-label, case-controlled trial for acarbose add-on therapy. Totally 111 (73 non-obese and 38 obese) patients completed 3-month acarbose add-on therapy. This study adopted a 2-center open-label parallel group design. After a 4-week run-in period, acarbose was added (ti-trated up to 100 mg t.i.d.) to the current sulfony-lureas and metformin combined therapy of sub-jects. Both obese patients (9.3±1.3% vs. 8.3±1.6%, p | en |
| DOI | https://doi.org/ | en |
| Keyword | Type 2 diabetes mellitus | en |
| Keyword | Acarbose | en |
| Keyword | Obesity | en |
| Publisher | Brieflands | en |
| Title | Differential Responses to Acarbose Between Obese and Non-obese Patients with Type 2 Diabetes Mellitus | en |
| Type | Research Article | en |
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