Non-Invasive Markers of Liver Fibrosis in Children with Chronic Hepatic Disorders
| Author | Iraj Shahramian | en |
| Author | Manijeh Khalili | en |
| Author | Alireza Sargazi | en |
| Author | Alireza Dechal | en |
| Author | Mostafa Bazi | en |
| Author | Masoud Jahantigh | en |
| Author | Mojtaba Delaramnasab | en |
| Author | Ali Bazi | en |
| Orcid | Iraj Shahramian [0000-0002-4134-1405] | en |
| Orcid | Manijeh Khalili [0000-0001-6754-5011] | en |
| Orcid | Alireza Sargazi [0000-0003-1937-6051] | en |
| Orcid | Mojtaba Delaramnasab [0000-0002-2958-3671] | en |
| Orcid | Ali Bazi [0000-0003-4872-1352] | en |
| Issued Date | 2020-07-29 | en |
| Abstract | Background: The applicability of non-invasive markers for predicting hepatic fibrosis in the pediatric population with chronic liver abnormalities is unclear. Objectives: We investigated the applicability of common non-invasive liver fibrosis parameters for detecting liver fibrosis in children with chronic hepatitis. Methods: This was a double-center study in Amir-Almomenin Hospital of Zabol and Namazi Hospital of Shiraz (2015 - 2017). Liver fibrosis was confirmed by biopsy examination. AST to platelet ratio (APRI), AST to ALT ratio (AAR), and Fibrosis-4 (FIB-4) were evaluated. Results: Out of 47 patients, 23 (48.9%) were females, and 24 (51.1%) were males. The mean age was 9.8 ± 11.3 months. APRI and FIB-4 correlated with fibrosis stages (r = 0.1 and r = 0.2, respectively). APRI showed an AUC of 0.541 for detecting non-advanced fibrosis (stages 0, 1, and 2). AAR and FIB-4 represented AUCs of 0.622 and 0.592 for advanced fibrosis and cirrhosis, respectively. The highest sensitivity of APRI (70%) was obtained at the cut-off point of 0.81 for cirrhosis. The highest specificities for APRI were observed at 0.66 (68%) and 1.37 (68%) for fibrotic stages 0 and 2, respectively. At the thresholds of 0.71 and 0.59, AAR rendered 78% sensitivity and 90% specificity for advanced fibrosis (stages 3 and 4) and no fibrosis (stage = 0), respectively. FIB-4 showed the highest sensitivity and specificity (70% and 60%) at the cut-off point of 0.21 for detecting cirrhosis. Conclusions: APRI, FIB-4, and AAR can be regarded as useful markers in predicting fibrotic transformation in children with various etiologies of chronic hepatitis. | en |
| DOI | https://doi.org/10.5812/gct.101443 | en |
| Keyword | Liver Cirrhosis | en |
| Keyword | Biopsy | en |
| Keyword | Pediatrics | en |
| Keyword | Hepatitis | en |
| Publisher | Brieflands | en |
| Title | Non-Invasive Markers of Liver Fibrosis in Children with Chronic Hepatic Disorders | en |
| Type | Research Article | en |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- gct-7-3-101443.pdf
- Size:
- 483.43 KB
- Format:
- Adobe Portable Document Format
- Description:
- Article/s PDF