Ventricular Systolic and Diastolic Function and Vitamin D Levels: An Echocardiographic Study of Normal Coronary Patients

Abstract

Background: Despite growing evidence linking Vitamin D (Vit-D) deficiency with heart dysfunction, objective evidence such as echocardiographic findings remains limited and inconclusive. Objectives: This study aims to investigate the association between Vit-D levels and both systolic and diastolic function of the ventricles in patients with normal coronary arteries using echocardiography. Methods: This study, conducted between 2019 and 2020, examined individuals without apparent coronary artery disease (CAD). The researchers measured the participants' Vit-D levels and divided them into two groups based on a 30 ng/dL cut-off point. All patients underwent echocardiography, and the researchers analyzed and compared their ventricular systolic function characteristics. Results: A total of 27 patients with normal Vit-D levels and 47 patients with Vit-D deficiency were included in the study. There was no significant difference between the left ventricle (LV) and right ventricle (RV) systolic function parameters, including left ventricular ejection fraction (LVEF), LV end-systolic/diastolic volume, and tricuspid annular plane systolic excursion. The mean LVEF between the patients with normal Vit-D levels (53%) and those with Vit-D deficiency (57%) did not show a significant difference (P = 0.420). Right ventricle diastolic parameters, such as A, E, E', deceleration time (DT), and Right Atrial Volume Index (RAVi), also did not show a significant difference between the two groups. However, patients with Vit-D deficiency had higher diastolic blood pressure (DBP) (P = 0.019). Conclusions: The results of this study indicate that there is no significant correlation between Vit-D levels and systolic dysfunction in the right and LV s of individuals with normal coronary arteries. However, it is important to note that this is a complex area of study, and further research is needed.