Fabrication of Gelatin Nano-Capsules Incorporate <i>Ferula assa-foetida</i> Essential Oil With Antibacterial and Antioxidant

Abstract

Background:: Manufacturing Gelatin nano-capsules merged with Ferula assa-foetida essential oil, antioxidant and antibacterial properties to produce drugs with properties targeted drug delivery to the body. Objectives:: In this study, we proved that gelatin nano-capsules grafted with F. assa-foetida essential oil have excellent physical, well as good antioxidant and antibacterial activity, which is suitable for producing nano-capsules of antioxidant antibacterial drug. Materials and Methods:: In this experimental study, gelatinnano-capsules were prepared from gelatin solutions (10% w/v) containing F. assa-foetida essential oil (FAO) (2, 4, 6 and 8% w/w), glycerol (25% w/w) as plasticizer and glutaraldehyde (2% w/w) as cross-linker. The morphology, antioxidant and antibacterial properties of the nano-capsules were achieved according to American Society for Testing and Materials. Results:: Gelatin nano-capsules exhibited low antioxidant activity while gelatin nano-capsules incorporated with FAO exhibited excellent antioxidant properties. The nano-capsules incorporated with FAO also exhibited excellent antibacterial properties against both Gram-positive and Gram-negative bacteria. Conclusions:: According to the results, gelatin nano-capsules are good nominations for a variety of antibiotic replacement industrial. The nano-capsules as well as due to the risk of bacterial resistance stay safe. The nano-capsules according to the origin of the whole plant do not have any negative effects on the body.