Fabrication of Gelatin Nano-Capsules Incorporate <i>Ferula assa-foetida</i> Essential Oil With Antibacterial and Antioxidant
| Author | Somayeh Jahani | en |
| Author | Amin Shakiba | en |
| Author | Leila Jahani | en |
| Issued Date | 2015-07-29 | en |
| Abstract | Background:: Manufacturing Gelatin nano-capsules merged with Ferula assa-foetida essential oil, antioxidant and antibacterial properties to produce drugs with properties targeted drug delivery to the body. Objectives:: In this study, we proved that gelatin nano-capsules grafted with F. assa-foetida essential oil have excellent physical, well as good antioxidant and antibacterial activity, which is suitable for producing nano-capsules of antioxidant antibacterial drug. Materials and Methods:: In this experimental study, gelatinnano-capsules were prepared from gelatin solutions (10% w/v) containing F. assa-foetida essential oil (FAO) (2, 4, 6 and 8% w/w), glycerol (25% w/w) as plasticizer and glutaraldehyde (2% w/w) as cross-linker. The morphology, antioxidant and antibacterial properties of the nano-capsules were achieved according to American Society for Testing and Materials. Results:: Gelatin nano-capsules exhibited low antioxidant activity while gelatin nano-capsules incorporated with FAO exhibited excellent antioxidant properties. The nano-capsules incorporated with FAO also exhibited excellent antibacterial properties against both Gram-positive and Gram-negative bacteria. Conclusions:: According to the results, gelatin nano-capsules are good nominations for a variety of antibiotic replacement industrial. The nano-capsules as well as due to the risk of bacterial resistance stay safe. The nano-capsules according to the origin of the whole plant do not have any negative effects on the body. | en |
| DOI | https://doi.org/10.17795/zjrms1018 | en |
| Keyword | Gelatin | en |
| Keyword | Capsules | en |
| Keyword | <i>Ferula assa-foetida</i> | en |
| Keyword | Antioxidant | en |
| Keyword | Antibacterial | en |
| Publisher | Brieflands | en |
| Title | Fabrication of Gelatin Nano-Capsules Incorporate <i>Ferula assa-foetida</i> Essential Oil With Antibacterial and Antioxidant | en |
| Type | Research Article | en |