Effects of Dimethyl Phthalate (DMP) on Serum Sex Hormone Levels and Apoptosis in C57 Female Mice
| Author | Yue Mei | en |
| Author | Ma Rongshuang | en |
| Author | Zhang Ruizhi | en |
| Author | Huang Hongyuan | en |
| Author | Tan Qiyue | en |
| Author | Zhao Shuhua | en |
| Issued Date | 2019-04-30 | en |
| Abstract | Background: The effects of dimethyl phthalate (DMP) on the reproductive system of mammal females are unclear because no studies have been conducted on this topic. Methods: In this study, 40 C57 female mice were used as experimental subjects and evenly divided into 8 groups, which were fed with mixed DMP (0, 0.5, 1, and 2 g/kg bw/day) and corn oil. After 20 days and 40 days of gavage, the mice were weighed and their individual ovary organ coefficients measured. Results: Changes were discovered on progesterone, estradiol, follicle-stimulating hormone and luteinizing hormone in mouse serum, and on the apoptosis rate of ovarian granulosa cells. Conclusions: Prolonged exposure to DMP led to decreased secretion of FSH hormones and increased secretion of E2 and LH hormones. Furthermore, DMP interfered with the pituitary-ovary axis and increased the apoptosis rate of ovarian granulosa cells. Therefore, prolonged exposure to DMP is likely to have negative effects on reproduction and development. | en |
| DOI | https://doi.org/10.5812/ijem.82882 | en |
| Keyword | Dimethyl Phthalate | en |
| Keyword | Sex Hormone | en |
| Keyword | Apoptosis | en |
| Keyword | Endocrine Disruptors | en |
| Publisher | Brieflands | en |
| Title | Effects of Dimethyl Phthalate (DMP) on Serum Sex Hormone Levels and Apoptosis in C57 Female Mice | en |
| Type | Research Article | en |
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