Studying the Effect of Probiotics on Liver Factors and Disease Recovery in People with Hepatitis (Review)

Abstract

Context: There is a common connection between the liver and the intestine, which is the main factor in the health of both organs. The bacterial flora in the intestine plays a very important role in improving the functions of liver cells; any change in the number and type of these microorganisms causes significant disorders in the liver. Methods: This study was conducted by searching for articles on various sites with keywords in Persian and English. Results: The results of various studies showed that the use of combination treatments with probiotic bacteria can have good protective effects against liver diseases, including hepatitis. Preliminary studies and clinical trials have shown that probiotics can reduce liver damage and accelerate cell repair by reducing systemic inflammation, improving intestinal barrier function, and regulating the immune response. In various liver diseases such as nonalcoholic fatty liver disease and chronic hepatitis, the use of probiotics has had positive results. Liver biomarkers such as alanine aminotransferase (ALT) and aspartate aminotransferase (AST) are sensitive and reliable indicators of liver cell damage, whose levels increase during inflammation and injury. A faster decrease in these enzymes can indicate a quicker recovery of liver damage. Therefore, examining the effect of probiotics on changes in these biomarkers and also determining the time required for enzymes to return to normal levels can more accurately determine the role of this intervention. Conclusions: In addition to helping to better understand the mechanisms of action of probiotics, the results of this study can provide valuable guidance for physicians in choosing adjuvant treatments and improving the quality of life of people with this disease. Finally, this study can play an important role in the development of health and medical policies at the national level and serve as a basis for future research in the field of the use of probiotics in viral liver diseases of patients.