Studying the Effect of Rosemary Hydroalcoholic Extract in Improving Polycystic Ovary Syndrome Induced by Letrozole in Mice

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AuthorGhazal Sadat Eftekhar Vaghefien
AuthorHoma Mohseni Kouchesfehanien
AuthorMahnaz Azarniaen
AuthorElaheh Aminien
AuthorNasim Naeimien
Issued Date2025-09-30en
AbstractBackground: Disruption of normal ovulation and hormonal imbalances, especially androgens, can lead to infertility in women. This condition can lead to irregular menstrual cycles and other symptoms that characterize polycystic ovary syndrome (PCOS). Rosemary is a member of the Lamiaceae family and has potential medicinal properties that may offer benefits in managing conditions like PCOS. Objectives: This study aimed to investigate the effects of Rosemary hydroalcoholic extract on some attributes caused by letrozole on PCOS in female mice. Methods: The PCOS was induced by 1 mg/kg of letrozole and then mice received Rosemary (50, 100, and 200 mg/kg) for 30 days. Estrogen level, CYP19A1 gene expression, morphometric indices, and total triglyceride (TG) concentration were measured at the end of the intervention. Results: Comparison let+Ros 200 mg/kg and letrozole groups showed a significant difference in increasing the estrous phase and CYP19A1 gene expression, decreasing the levels of TG and estrogen hormones, as well as increasing the number of growing follicles (P < 0.01). Conclusions: Considering that anovulation increases the risk of genital cancer and infertility, we suggest that the compounds in Rosemary may act as a therapeutic agent for PCOS.en
DOIhttps://doi.org/10.5812/jkums-159930en
KeywordRosemary Hydroalcoholic Extracten
KeywordPolycystic Ovary Syndromeen
KeywordEstrogen Hormoneen
KeywordCYP19A1 Geneen
KeywordEstrous Phaseen
KeywordTriglycerideen
PublisherBrieflandsen
TitleStudying the Effect of Rosemary Hydroalcoholic Extract in Improving Polycystic Ovary Syndrome Induced by Letrozole in Miceen
TypeResearch Articleen

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Journal of Kermanshah University of Medical Sciences