Zinc Chloride Reverse Influence on Dexamethasone Depressant Effects in Adult Male Rats
| Author | Seyedeh Parisa Navabi | en |
| Author | Hooman Eshagh Harooni | en |
| Author | Ahmad Ali Moazedi | en |
| Author | Lotfolah Khajehpour | en |
| Issued Date | 2015-12-01 | en |
| Abstract | Background: Cumulative evidence shows that dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis is involved in the depressive disorders and natural or synthetic glucocorticoids have a direct effect on HPA activity. Objectives: Considering the reports that show zinc deficiency is one of the causes of depressive-like behavior, the current study aimed to examine the effects of systemic injection of zinc chloride (ZnCl2) and/or dexamethasone sodium-phosphate (DEX) on depression in adult male rats. Materials and Methods: Different groups received ZnCl2 (2.5, 5, 10, and 20 mg/kg) and DEX (0.5, 1, 5, 10, and 30 mg/kg) and then depression was assessed in the forced swimming test (FST). Results: Results showed that DEX 1 significantly increased, while DEX 30 and groups treated with zinc 10 mg/kg and zinc 20 mg/kg decreased total immobility time as compared to that of saline group. Also there was a significant decrease of total immobility time when zinc administered to rats already received DEX 1, compared with that of control group. Conclusions: The current study findings suggest that zinc has antidepressant effects dose dependently, while administration of DEX induced dual effects on depression; therefore, a low dose of DEX showed an increased level of depressive-like behavior while higher doses had antidepressant effects. Also, results showed that zinc administration could ameliorate depressive-like behavior induced via dexamethasone in FST. | en |
| DOI | https://doi.org/10.17795/jjhr-24297 | en |
| Keyword | Dexamethasone | en |
| Keyword | Depression | en |
| Keyword | Glucocorticoids | en |
| Keyword | Male Rat | en |
| Keyword | Zinc | en |
| Publisher | Brieflands | en |
| Title | Zinc Chloride Reverse Influence on Dexamethasone Depressant Effects in Adult Male Rats | en |
| Type | Research Article | en |
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