The Effect of Preoperative Combined with Intravenous Lidocaine and Ketamine vs. Intravenous Ketamine on Pediatric Patients Undergoing Upper Gastrointestinal Endoscopy
| Author | Amir Shafa | en |
| Author | Reza Abediny | en |
| Author | Hamidreza Shetabi | en |
| Author | Sedighe Shahhosseini | en |
| Orcid | Amir Shafa [0000-0001-5281-3458] | en |
| Orcid | Reza Abediny [0000-0001-5753-5119] | en |
| Orcid | Hamidreza Shetabi [0000-0003-3577-3006] | en |
| Orcid | Sedighe Shahhosseini [0000-0002-8494-3019] | en |
| Issued Date | 2023-04-30 | en |
| Abstract | Background: Ketamine is widely used in pediatric sedation. New studies have recommended combination therapy to reduce the side effects of ketamine. Objectives: This study investigated the effect of adding intravenous (IV) lidocaine to ketamine on hemodynamic parameters, endoscopist satisfaction, and recovery time of children undergoing gastrointestinal endoscopy. Methods: This triple-blind, randomized, controlled clinical trial was conducted in Isfahan, Iran (2021). One hundred twenty children between the ages of 1 and 6 were enrolled. Patients were divided into 2 groups. The intervention group received 1.0 mg/kg of IV lidocaine and 1.0 mg/kg of IV ketamine, and the placebo group received 1.0 mg/kg of IV ketamine and placebo 2 minutes before entering the endoscopic room. Patients in both groups were sedated with 1.0 mg/kg of propofol, 0.1 mg/kg of midazolam, and 2.0 ug/kg of fentanyl for the procedure. The pulse rate, mean arterial pressure (MAP), respiratory rate, and oxygen saturation were recorded 1 minute before injection and every 5 minutes afterward. Results: The mean (SD) ages of the intervention and control groups were 3.4 (1.5) and 3.4 (1.7), respectively. The mean difference in hemodynamic parameters between the 2 groups was insignificant during the investigation (P > 0.05). Furthermore, no significant differences were found regarding endoscopist satisfaction scores and length of recovery room stay (P > 0.05). Conclusions: Adding low-dose IV lidocaine to ketamine for pediatric sedation does not significantly affect the hemodynamic status, endoscopist satisfaction, and recovery time. | en |
| DOI | https://doi.org/10.5812/aapm-130991 | en |
| URI | https://brieflands.com/journals/aapm/articles/130991 | en |
| Keyword | Lidocaine | en |
| Keyword | Ketamine | en |
| Keyword | Pediatrics Endoscopy | en |
| Publisher | Brieflands | en |
| Title | The Effect of Preoperative Combined with Intravenous Lidocaine and Ketamine vs. Intravenous Ketamine on Pediatric Patients Undergoing Upper Gastrointestinal Endoscopy | en |
| Type | Research Article | en |
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