Comparison of Dexmedetomidine and Morphine as Adjuvants to Bupivacaine for Epidural Anesthesia in Leg Fracture Surgery: A Randomized Clinical Trial
| Author | Mohammadreza Gousheh | en |
| Author | Reza Akhondzadeh | en |
| Author | Mahbobe Rashidi | en |
| Author | Alireza Olapour | en |
| Author | Fatemeh Moftakhar | en |
| Orcid | Reza Akhondzadeh [0000-0002-5476-1505] | en |
| Orcid | Fatemeh Moftakhar [0000-0002-1870-3754] | en |
| Issued Date | 2019-08-27 | en |
| Abstract | Background: Epidural block approach and drugs are common options for improving the sensory and motor block duration and postoperative pain management. Objectives: The study aimed to compare the analgesic effects of dexmedetomidine and morphine as adjuvants to bupivacaine for epidural anesthesia in leg fracture surgery. Methods: This prospective clinical trial was conducted on patients (n = 80, age range: 18 - 60 years) categorized as ASA class I or II. After a clinical examination, the patients were allocated to receive either lumbar epidural bupivacaine + morphine (BM) (12 mL bupivacaine 0.5% + morphine 2 mg) or bupivacaine + dexmedetomidine (BD) (12 mL bupivacaine 0.5% + dexmedetomidine 1 µg/kg). After drug administration, the sensory block level was assessed at 2-min intervals using the Cold Swab method until it reached the T12 level. At the T12 level of sensory block, the surgery began when motor block reached grade 3 of the modified Bromage scale. Results: The BD group had a significantly shorter time to reach the sensory and motor block than the BM group (P < 0.001). The duration of sensory and motor block was significantly longer in the group BD than in the BM group (P < 0.001). Moreover, the BD group showed lower VAS scores (P < 0.0001) and longer time to first analgesia demand than the BM group. Conclusions: Combined bupivacaine + dexmedetomidine prolongs the sensory and motor block duration and controls postoperative pain more effectively, indicating that it is an appropriate combination for epidural anesthesia. | en |
| DOI | https://doi.org/10.5812/aapm.91480 | en |
| Keyword | Bupivacaine | en |
| Keyword | Dexmedetomidine | en |
| Keyword | Epidural Anesthesia | en |
| Keyword | Morphine | en |
| Publisher | Brieflands | en |
| Title | Comparison of Dexmedetomidine and Morphine as Adjuvants to Bupivacaine for Epidural Anesthesia in Leg Fracture Surgery: A Randomized Clinical Trial | en |
| Type | Research Article | en |
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