Investigation of SARS-CoV-2 Ability to Pass Through the Placenta
| Author | Fahimeh Ghotbizadeh | en |
| Author | Farzaneh Nazari | en |
| Author | Sedigheh Hantoushzadeh | en |
| Author | Zahra Panahi | en |
| Author | Zahra Naeiji | en |
| Orcid | Fahimeh Ghotbizadeh [0000-0002-2653-8429] | en |
| Orcid | Sedigheh Hantoushzadeh [0000-0003-3779-9218] | en |
| Issued Date | 2021-07-31 | en |
| Abstract | Context: Recently, a new coronavirus (SARS-CoV-2) as the cause of COVID-19 has made a global health crisis and a great challenge. Pregnant women and fetuses are among the high-risk groups for COVID-19. In this review, we summarize studies regarding SARS-CoV-2 virus-placenta interactions at the maternal-fetal interface by demonstrating the pathogenicity of the virus and defense methods of the placenta. Evidence Acquisition: In the present study, a search was done in domestic and international databases including Google Scholar, Web of Science, PubMed, and Scopus using specific keywords (“Coronavirus” OR “COVID-19” OR “SARS-CoV-2”) AND (“Fetus” OR “Placenta”) AND (“Pregnancy”), limited until August 2020. Finally, we reviewed 250 articles. Results: Generally, the pathogenicity and the life cycle of SARS-CoV-2 and virus entry and replication methods allow the virus to pass through the placenta, although there are hormonal and immune barriers in the placenta against SARS-CoV-2, such as placental type interferons. Conclusions: The SARS-CoV-2 can pass through the placenta, but there are defense methods against it. | en |
| DOI | https://doi.org/10.5812/semj.110047 | en |
| Keyword | SARS-CoV-2 | en |
| Keyword | Placenta | en |
| Keyword | Fetus | en |
| Keyword | Pregnancy | en |
| Keyword | COVID-19 | en |
| Publisher | Brieflands | en |
| Title | Investigation of SARS-CoV-2 Ability to Pass Through the Placenta | en |
| Type | Review Article | en |