The effects of cimetidine on motor activity: an evaluation the role of opioid receptors

Simple item page
AuthorHossein Miladi-Gorgien
AuthorAli RashidiPoren
AuthorMohammad Forozeshen
AuthorAbassAli Taherianen
AuthorAbassAli Vafaeien
AuthorHasan Sadeghien
Issued Date2006-09-30en
AbstractIntroduction: Effects of cimetidine (CIM) on locomotor is controversial. This study was designed to evaluate the effects of CIM on motor activity and possible roles of opioid receptors in CIM-induced decrement in locomotor activity in mice. Materials & Methods: Thirty-six male mice (25-30gr) were divided into six groups in this study. Locomotor activity was evaluated using an automated activity monitor system. CIM (50 mgkg, i.p.) was injected 25 min before testing in presence or absence naloxone (2 mg/kg, sc). Morphine (5 mg/kg, i.p) was injected 25 min before testing in the presence or absence CIM. decreased motor activity significantly. Pretreatment of or morphine did not change CIM – induced response significantly. Results: The results showed that CIM significantly decreased motor activity in mice (P=0.000). Pretreatment of nalxone did not change CIM-induced response significantly. Morphine alone did not change motor activity. Pretreatment of CIM did not change morphine-induced response. Conclusion: Data indicated that cimetidine can reduce motor activity independence from interaction with opioid receptors.en
DOIhttps://doi.org/en
KeywordMotor activity, Cimetidine, Morphine, Opioid receptor, Histaminic receptor, Naloxaneen
Keywordفعالیت حرکتی، سایمتیدین، مرفین، گیرنده اوپیوییدی، گیرنده هیستامینی، نالوکسانen
PublisherBrieflandsen
TitleThe effects of cimetidine on motor activity: an evaluation the role of opioid receptorsen
TypeResearch Articleen

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
article-1-90-fa.pdf.pdf
Size:
201.37 KB
Format:
Adobe Portable Document Format
Description:
Article/s PDF
Download

Collections

Koomesh