Association Between the -1031 (T/C) Polymorphism of TNF-α Gene and Biochemical Factors in Women With Polycystic Ovary Syndrome
| Author | Mehdi Sahmani | en |
| Author | Talaate Dabaghi Ghaleh | en |
| Author | Maryam Yargholi | en |
| Author | Farshad Foroughi | en |
| Author | Amir Javadi | en |
| Author | Khadijeh Taherkhani | en |
| Orcid | Amir Javadi [0000-0001-7715-4583] | en |
| Issued Date | 2021-03-31 | en |
| Abstract | Background: Tumor Necrosis Factor Alpha (TNF-α) gene, as an inflammatory factor, plays an important role in reproductive physiology, especially in women with Polycystic Ovary Syndrome (PCOS). Objective: This study aims to investigate the relationship between the -1031 T/C polymorphism of TNF-α gene and biochemical factors in women with PCOS. Methods: In this case-control study, participants were 106 women with PCOS and 114 healthy women referred to Kosar Hospital in Qazvin, Iran. The TNF-α gene’s polymorphism was determined using Polymerase Chain Reaction (PCR) technique and PCR-Restriction Fragment Length Polymorphism (PCR-RFLP) method. Biochemical factors of serum levels were also measured in two groups. Logistic regression analysis examined the relationship between the frequency of alleles in different states and the risk of PCOS. Findings: There were statistically significant difference in the mean levels of total cholesterol, triglycerides, testosterone, two-hour blood glucose and body mass index between the groups, whose values were higher in women with PCOS compared to healthy women (P | en |
| DOI | https://doi.org/ | en |
| Keyword | Polycystic ovary syndrome | en |
| Keyword | TNF-α | en |
| Keyword | Gene polymorphism | en |
| Publisher | Brieflands | en |
| Title | Association Between the -1031 (T/C) Polymorphism of TNF-α Gene and Biochemical Factors in Women With Polycystic Ovary Syndrome | en |
| Type | Research Article | en |